Of course! Valencia, Murcia, and Cartagena are all amazing cities in Spain and you're sure to have a great time exploring them. Here are some travel tips for each:

Best Time to Visit:
The best time to visit these Spanish cities are during the Spring (April to June) and Autumn (September to November) seasons when the weather is not too hot and tourist crowds are smaller.

Route and Accessibility:
The most convenient way to go from Valencia to Murcia and then to Cartagena is by car or train. The distance between Valencia and Murcia is approximately 220km and takes about 2.5 hours by car. From Murcia, Cartagena is about 50 km away and takes less than an hour by car.

Altitude and Acclimatization:
These cities are located at sea level, so no specific acclimatization is needed.

Accommodation and Booking:
Accommodations range from budget to luxury in all three cities. Booking in advance is advised to ensure you secure a good deal and avoid disappointment, especially during the peak tourist season.

Clothing and Essentials:
Comfortable walking shoes are recommended as these cities are great to explore on foot. You'll also need a hat, sunglasses, and sunscreen to protect from the sun. Don't forget to pack a light jacket or sweater as the evenings can sometimes get cool.

Health and Safety:
Overall, these cities are safe for tourists. However, it’s always wise to have travel insurance that covers health issues or accidents. Keep small change and avoid showing off expensive belongings in crowded places to avoid pickpocketing.

Local Etiquette and Respect:
Spanish people are known for their friendliness and hospitality. Be respectful of local customs and traditions. A basic understanding of Spanish phrases can go a long way in interacting with locals.

Enjoy the great food, stunning architecture, and vibrant nightlife that these cities have to offer!