Definitely! Melbourne, Bendigo, Ballarat, and Daylesford in the state of Victoria, Australia each boast their unique charms. Here are some travel tips for your trip:

Best Time to Visit:
The best time to visit these places would be during the spring (September to November) and autumn (March to May), where the temperatures are pleasant, and the landscapes are the most beautiful. Additionally, these are not peak tourist seasons, which means less crowd.

Route and Accessibility:
All four destinations are accessible by car and the V/Line trains, which run regularly from Melbourne's Southern Cross Station. If you plan to use public transport, research the schedules in advance.

Altitude and Acclimatization:
These Victoria cities are not located at high altitudes so acclimatization is generally not a concern. However, do check the weather forecasts before your travel as the temperature can vary.

Accommodation and Booking:
Countless accommodations options are available from luxury hotels to budget stays. Try to book in advance to avoid any last-minute troubles and to get the best deals.

Clothing and Essentials:
Daytime temperatures can considerably vary from nighttime ones, especially in Melbourne. Pack a mix of clothes suitable for both hot and cold weather. A good pair of walking shoes, a hat, and sunscreen are essentials.

Health and Safety:
Australia has a high standard of healthcare. Regardless, it’s a good idea to have travel insurance. If you have prescriptions, bring enough medication to cover your visit time.

Local Etiquette and Respect:
Australians are generally casual and easy-going. Remember to respect the local customs and manners. Tipping is not a standard practice in Australia, but it is appreciated for good service.

When visiting Daylesford, well known for its mineral springs, be aware of preserving their natural habitat. And when exploring the gold rush history of Bendigo and Ballarat, respect historical sites. In Melbourne, appreciate the rich indigenous culture and street art the city boasts.