Absolutely! Here are some recommendations for your visit to Curitiba, Gramado, and Blumenau in Brazil.

Best Time to Visit:
For Curitiba, given its subtropical highland climate, the most pleasant time to visit is during the dry season, between April and September. Gramado is a perfect year-round destination, but it's particularly beautiful around Christmas when the city hosts its annual Natal Luz festival. Blumenau is famous for its Oktoberfest so if you’re a fan of beer, you might consider timing your visit to coincide with these festivities.

Route and Accessibility:
You can easily reach all three cities by bus or by flying into the closest airports - Afonso Pena Airport (Curitiba), Salgado Filho Airport (Porto Alegre, the closest airport to Gramado) and Ministro Victor Konder airport (Closest to Blumenau). From these points, you can rent a car or take a bus to reach your destination.

Altitude and Acclimatization:
These places aren't very high in altitude, so you won't need specific acclimatization. However, it's always necessary to keep hydrated and rest when needed.

Accommodation and Booking:
All these cities have a wide range of accommodations from budget to luxury. Always book your accommodation in advance, especially during the high season or during special events like the Oktoberfest in Blumenau.

Clothing and Essentials:
Given the temperate climate, lightweight clothing is generally suitable. However, during winter evenings, you may need a light sweater or jacket. A raincoat or umbrella can also be handy as rain can sometimes be unpredictable in these areas.

Health and Safety:
Always have travel insurance. Even though these cities are relatively safe, it's always better to be prepared for any possible health issues or accidents.

Local Etiquette and Respect:
Brazilian culture is warm and welcoming. In terms of etiquette, it's important to respect local traditions and customs. Dress modestly when visiting religious sites.

In conclusion, These cities are fantastic tourist destinations and you're bound to have a great time exploring them!