Absolutely! Cape Town, Hermanus, and Johannesburg are some of South Africa's most beloved destinations. Here are few travel tips:

Best Time to Visit:
Cape Town and Johannesburg are great to visit all year round. However, for Cape Town, the summer months of November through February are particularly inviting since the city comes alive with summer activities. Johannesburg is best visited during autumn (March to May) and spring (September to November) when the weather is milder.
Hermanus has a peak tourist season in September and October during the whale watching season.

Route and Accessibility:
All three cities are well-connected via road, rail, and air. The quickest way to travel between them is by taking domestic flights.

Altitude and Acclimatization:
Johannesburg is a high-altitude city, but most people acclimatize quite easily. Cape Town and Hermanus lie at sea level, so altitude acclimatization isn't necessary for most people.

Accommodation and Booking:
Accommodation options range from luxurious hotels to budget friendly hostels and B&Bs. Book in advance, especially if you're travelling during peak seasons.

Clothing and Essentials:
Cape Town and Hermanus can get quite windy, so take a windcheater along. Don't forget sunscreen, a hat and sunglasses due to the intensity of the sun in South Africa, regardless of the season you plan to visit.
In Johannesburg, the temperature fluctuations during the same day can be quite significant, so pack both warm and cool clothes.

Health and Safety:
Always remain aware of your surroundings and avoid isolated areas in the cities, especially after dark. Have a reliable cab service number handy.

Local Etiquette and Respect:
South Africans are generally warm and welcoming. Be respectful of local customs and traditions. It's polite to tip in restaurants and to taxi drivers; usually 10% to 15% of the bill is considered a standard tip.