Absolutely! Visiting Lima, Buenos Aires, and Santiago is a great way to experience the rich and vibrant cultures of South America. Here are some travel tips for your journey:

Best Time to Visit:
Lima, Peru:
The best time to visit Lima is during their summer (December through April). If you don't enjoy hot weather, May to November might be more suitable for you offering a cooler and overcast climate.
Buenos Aires, Argentina:
The best time to visit is during the springtime (September to November) and fall (March to May) when the weather is mild.
Santiago, Chile:
Southern Hemisphere’s spring (September to November) or fall (March to May) is fantastic to get there.

Route and Accessibility:
You can reach all three cities via international flight. Numerous carriers offer connections connecting all continents.

Altitude and Acclimatization:
Lima and Buenos Aires are both at moderate altitudes and Santiago is located in a valley, so altitude sickness won't be a problem.

Accommodation and Booking:
All three cities have a variety of accommodations to cater all budgets from hostels to luxury hotels. It's recommended to book accommodations in advance.

Clothing and Essentials:
Pack lightweight and breathable clothing for the day and warmer clothes for the night. Sunscreen, hat and sunglasses are a must for the sunny weather.

Health and Safety:
Stay hydrated and protect yourself from the sun. Use caution when eating street food and only drink bottled water to avoid potential food poisoning. Beware of pickpockets in crowded areas.

Local Etiquette and Respect:
It's important to respect all the local traditions and customs of these South American cities. Spanish is the official language and while many people speak English, it's appreciated when visitors make an effort to converse in the local language.