Absolutely, I'd be happy to assist you.

Best Time to Visit:
The best time to visit Mérida, Trujillo and San Cristóbal is generally from December to April when the weather is pleasant and there's lesser rain. However, you might want to avoid the most crowded months, such as December and January.

Route and Accessibility:

For Mérida, you can fly into Alberto Carnevalli Airport from Caracas. Trujillo can be reached by road from Caracas or Mérida. San Cristóbal is also accessible by road and has its own airport, Mayor Buenaventura Vivas Airport.

Altitude and Acclimatization:

While Mérida is located at significant altitude (1,600 m), Trujillo and San Cristóbal are at lower elevations. To help your body acclimatize to Mérida's altitude, try to rest on your first day, stay hydrated, and avoid strenuous activities.

Accommodation and Booking:

You will find various options for accommodations- from budget to luxury hotels. It's highly recommended to book your stays well in advance, particularly if you're planning to visit during peak tourist seasons or local holidays.

Clothing and Essentials:

As there can be a significant temperature difference between day and night, layering your clothes is a good idea. Don't forget to bring a comfortable pair of walking shoes. Rainwear can also be helpful if you plan to visit in the rainy season.

Health and Safety:

Remember to always take care of your belongings and be vigilant in crowded places as petty theft can occur. If you need any medical assistance, there are hospitals and clinics available in all three cities.

Local Etiquette and Respect:
Venezuelans are generally warm and friendly. A respectful behaviour towards local customs and traditions is appreciated. When dining, it's customary to say "Buen provecho" before starting to eat, which is similar to saying "Bon appétit" or "Enjoy your meal".