Of course! These Texas cities have a lot to offer from sight seeing, food, and rich history. Here are some travel tips for you:

Best Time to Visit:
The best time to visit these cities in Texas is in the spring (April and May) or fall (September and October), when temperatures are comfortable, and there are ongoing festivals. However for cheaper hotel rates, you can consider the relatively cool winter months.

Route and Accessibility:
You could start your tour in Dallas, then move to Austin, then San Antonio and lastly Houston. The cities are well connected by highways, making it ideal for a road trip. There are also flights and trains connecting these cities.

Altitude and Acclimatization:
These cities lie in low to moderate altitude ranges, no specific acclimatization is required.

Accommodation and Booking:
There are numerous hotel chains, boutiques, and vacation homes for accommodation from luxury to budget options. Booking in advance can fetch you considerable discounts.

Clothing and Essentials:
Pack according to the season. Summers can be quite hot, so light breathable clothes, sunblock, sunglasses and a hat for outdoor activities would be useful. Winters are relatively mild, though you may need a sweater or light jacket.

Health and Safety:
Always stay hydrated, especially during the hot summer months. Keep a digital copy of important documents. Use sunscreen to protect against the strong southern sun, and carry an insect repellent if you plan to spend time outdoors.

Local Etiquette and Respect:
Texans are known for their friendliness. Politeness and respect go a long way. Don’t forget to try the renowned Texas BBQ, and Tex-Mex cuisine when you are there!