Definitely! Here’s your guide for your trip to Nashville, Memphis, and New Orleans:

Best Time to Visit:
September to November could be the best time as the weather is pleasant and this is less crowded tourist time. Although these cities have festivals and events year-round, so depending on your interests, you might want to plan according to the event schedule.

Route and Accessibility:
You can start your trip in Nashville, then head to Memphis, these two cities are directly connected via the I-40 route. From Memphis, you can take a drive down New Orleans through Jackson, Mississippi.

Altitude and Acclimatization:
These cities are at lower altitudes, so acclimatization is usually not an issue.

Accommodation and Booking:
There are numerous hotels and accommodations available in these cities. However, due to high demand especially during event season, booking in advance is recommended.

Clothing and Essentials:
These cities have a varied climate. Usually, lightweight clothing and a few light sweaters for cooler evenings would suffice. Do pack your comfortable walking shoes as these cities are best explored on foot.

Health and Safety:
Remember to stay hydrated, particularly during the summer months. In terms of safety, stick to well-lit areas at night, be cautious of your belongings especially in crowded areas.

Local Etiquette and Respect:
All 3 cities are culturally rich. Respect local traditions and customs. Tipping is standard in the USA, with 15-20% being usual in restaurants.

And lastly, enjoy the rich music culture of these cities:
Country music in Nashville, Blues in Memphis, and Jazz in New Orleans.