Hello! That sounds like a great adventure to Panama. Here are some travel tips to help you plan your trip to Penonomé, Ocú, and Las Tablas.

Best Time to Visit:
The best time to visit Panama, including Penonomé, Ocú and Las Tablas, is from mid-December to mid-April, which is when the country experiences its dry season. The weather is pleasant and it's the perfect time for sightseeing and outdoor activities.

Route and Accessibility:
Air travel is the most efficient way to enter Panama. From the Tocumen International Airport in Panama City, you can hire a car to reach Penonomé, which is about 2 hours away. Ocú and Las Tablas can be reached via the Panamerican Highway. Coming from Penonomé, you'll head south to Ocú, and from there head southeast to Las Tablas.

Accommodation and Booking:
Accommodation options in these regions range from luxury resorts to budget hostels. It's generally recommended to book your accommodation in advance, especially during peak tourist season. You can use various online platforms to compare prices and facilities.

Clothing and Essentials:
Pack lightweight clothes for Panama's tropical climate. Don't forget to bring your sunblock, hat, sunglasses, and repellents as well. A waterproof jacket or umbrella might come in handy in case it rains, and comfortable shoes are vital for exploring the towns and natural attractions.

Health and Safety:
Make sure your routine vaccinations are up to date before traveling. No specific vaccinations are required for Panama but it's recommended to get a Yellow Fever vaccine if you're traveling from a country where it's prevalent. Also, it might be a good idea to have a basic first-aid kit with you.

Local Etiquette and Respect:
Panamanians are generally friendly and polite. A handshake is a common form of greeting. It's considered respectful to dress modestly, particularly when visiting local communities or churches. Also, learn a few phrases in Spanish, as it is the primary language there.