Absolutely! Planning such a trip to Interlaken, Lucerne, Adelboden, and Zurich in Switzerland would be a fantastic experience. Here are a few tips to make your journey more enjoyable:

Best Time to Visit:
The best time to visit Switzerland for sightseeing and to enjoy scenic beauty is in the summer, from June to September. However, if you're a winter sports enthusiast, the period between December to March is perfect.

Route and Accessibility:
There are various efficient and scenic travel routes between these cities. Swiss trains are comfortable, reliable, and operate on time, whether you're travelling from Interlaken to Lucerne, Lucerne to Adelboden, or Adelboden to Zurich. The Swiss Travel Pass might be a good investment for you.

Altitude and Acclimatization:
Interlaken, Lucerne, Adelboden, and Zurich are not situated at high altitudes, so altitude sickness shouldn't be an issue, unlike mountainous trekking destinations.

Accommodation and Booking:
There are numerous hotels and guesthouses in these cities to suits every budget. It is recommended to book accommodation in advance, especially during peak tourist seasons.

Clothing and Essentials:
In summer, regular comfortable clothing would be fine. Don't forget to carry a light jacket or sweater as it can be a bit cooler in the mountains and at night. If you're travelling in winter, pack warm clothing. Good walking shoes are also recommended as the cities are best explored on foot.

Health and Safety:
Switzerland is overall a safe travel location. But it's advised to have comprehensive travel insurance coverage. Keep regular medication and a basic first-aid kit with you.

Local Etiquette and Respect:
Switzerland has four official languages (German, French, Italian and Romansh) and its culture varies by region. Try to greet people in the local language, it's appreciated. Swiss people value punctuality, so try to be on time. It's also important to respect the country's clean, quiet and ordered culture.