Absolutely! Here are some tips for your travel across these prominent Chinese cities:

Best Time to Visit:
The best time to visit these cities in China is during the autumn (September to early November) when the weather is clear and comfortable. You might want to avoid the national holidays like Golden Week (first week of October) due to crowd.

Route and Accessibility:
Commercial airlines service all four cities (Shanghai, Beijing, Guangzhou, Shenzhen). High-speed trains are also an efficient way to move from one city to another. For inner-city transportation, metros are convenient and taxis are affordable.

Altitude and Acclimatization:
All these cities are located close to sea level, so altitude sickness is not a concern. However, air pollution can be a worry in Beijing and Shanghai, so be prepared.

Accommodation and Booking:
There is a wide range of accommodations in these cities suitable for all budgets. Hotels often fill up quickly, especially during peak seasons, so it's better to book in advance.

Clothing and Essentials:
Carry clothing as per the season. The summers can be hot and humid while the winter colder especially in Beijing. In other seasons, a light jacket or sweater would be beneficial. Umbrella for sudden rains and comfortable shoes for walking are a must.

Health and Safety:
China is a safe country for travelers. However, remember to have travel insurance and keep local emergency contact numbers handy. Always use bottled water for drinking.

Local Etiquette and Respect:
Chinese respect modesty, so try to wear appropriate clothing. Learn a few basic Chinese phrases as not everyone will speak English. Respect local customs especially when visiting places of worship or historical sites.

Also, Google-based apps would not work in China as there is no Google. So, make sure to download other VPN services/apps beforehand so you stay connected. Don't forget to try their famous Chinese cuisines! Have a great trip!